Oncology nurses are at risk for negative health effects of exposure to hazardous chemotherapy drugs. The health effects of this occupational exposure include the increased risk for cancer, fertility problems, asthma, nausea, vomiting, and allergic reactions. Chemotherapy exposure occurs due to inadvertent contact with these drugs during handling procedures. While the rates of exposure to chemotherapy have decreased since the publication of hazardous drugs handling guidelines in the 1980s, nurses are still reporting exposure incidents. In this session, we will describe the patterns of exposure to chemotherapy and handling practices among oncology nurses based on results from a pilot survey study. Further, we will discuss the factors influencing the exposure and strategies to foster chemotherapy safety from the perspectives of nurses and nurse managers.